GASTROENTERITIS EOSINOFILICA PDF

Published by Baishideng Publishing Group Inc. All rights reserved. This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. This article has been cited by other articles in PMC.

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Correspondence to: Dr. All rights reserved. This article has been cited by other articles in PMC. Abstract Eosinophilic gastroenteritis EGE in the adult is a distinctive pathologically-based disorder characterized by an eosinophil-predominant mucosal inflammatory process.

Most often, the disorder is detected during endoscopic investigation for abdominal pain or diarrhea. Other causes of gastric and intestinal mucosal eosinophilia require exclusion, including parasitic infections and drug-induced causes.

Occasionally, the muscle wall or serosal surface may be involved. EGE appears to be more readily recognized, in large part, due to an evolution in the imaging methods used to evaluate abdominal pain and diarrhea, in particular, endoscopic imaging and mucosal biopsies. Definition of EGE, however, may be difficult, as the normal ranges of eosinophil numbers in normal and abnormal gastric and intestinal mucosa are not well standardized.

Also, the eosinophilic inflammatory process may be either patchy or diffuse and the detection of the eosinophilic infiltrates may vary depending on the method of biopsy fixation. Treatment has traditionally focused on resolution of symptoms, and, in some instances, eosinophil quantification in pre-treatment and post-treatment biopsies.

Future evaluation and treatment of EGE may depend on precise serological biomarkers to aid in definition of the long-term natural history of the disorder and its response to pharmacological or biological forms of therapy. Although most published material has focused largely on the pediatric population, this manuscript focuses on the adult with EGE.

Most often in adults, EGE is detected during endoscopic investigation for abdominal pain or diarrhea[ 1 - 4 ]. The mucosa of the stomach, intestine, or both may be involved most frequently. In one specific classification schema that included different forms of intestinal eosinophilic infiltration, involvement of the muscular layer or serosa was also described, but even in these, concomitant mucosal involvement was often present[ 5 ].

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Esofagite eosinofílica: definição e tratamentos

Correspondence to: Dr. All rights reserved. This article has been cited by other articles in PMC. Abstract Eosinophilic gastroenteritis EGE in the adult is a distinctive pathologically-based disorder characterized by an eosinophil-predominant mucosal inflammatory process.

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Adult eosinophilic gastroenteritis and hypereosinophilic syndromes

Occasionally, the disease may manifest itself as an acute abdomen or bowel obstruction. Failure to thrive and anaemia may also be present. Lower gastrointestinal bleeding may imply colonic involvement. Subserosal EG 4. Pathophysiology[ edit ] Peripheral blood eosinophilia and elevated serum IgE are usual but not universal. The damage to the gastrointestinal tract wall is caused by eosinophilic infiltration and degranulation. It is possible that different pathogenetic mechanisms of disease is involved in several subgroups of patients.

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Gastroenterite eosinofila

Fisiopatologia[ modifica modifica wikitesto ] Eosinofilia nel sangue periferico ed elevazione delle IgE nel siero sono rilievi comuni, ma non costanti. Nella gastroenterite eosinofila le citochine IL-3, IL-5 ed il fattore stimolante le colonie di granulociti macrofagi GM-CSF sono coinvolti nel reclutamento delle cellule e nella loro attivazione. Sono stati infatti osservati in preparazioni immunoistochimiche della parete intestinale malata. Si possono anche riscontrare ritardo di crescita ed anemia. La GE Sottosierosa dal 4.

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